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"The role of CYLD in PD-L1 expression was assessed by CYLD knockdown in tumor epithelial tumor cells ; CYLD knockdown significantly enhanced PD-L1 expression in the presence of interferon ( IFN ) - gamma stimulation in most cell lines , indicating that downregulation of CYLD promotes IFN-gamma-mediated PD-L1 expression [ 98 ] ."
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