IndraLab

Statements

CYLD inhibits CD274. 2 / 2
| 1 1
eidos
"The role of CYLD in PD-L1 expression was assessed by CYLD knockdown in tumor epithelial tumor cells ; CYLD knockdown significantly enhanced PD-L1 expression in the presence of interferon ( IFN ) - gamma stimulation in most cell lines , indicating that downregulation of CYLD promotes IFN-gamma-mediated PD-L1 expression [ 98 ] ."
| PMC
reach
"Mechanistically, the CXCL12/CXCR4 axis upregulates DUB cylindromatosis (CYLD) via JAK2/STAT3 signaling to facilitate p62 deubiquitination and accumulation, which suppresses the autophagic degradation of PD-L1 [131]."
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