IndraLab

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SRC inhibits KCNH2. 3 / 4
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"We found that the broad-spectrum PTK inhibitor genistein (30 microM), the selective EGFR (epidermal growth factor receptor) kinase inhibitor AG556 (10 microM) and the Src family kinase inhibitor PP2 (10 microM) remarkably inhibited hERG channel current (I (hERG)), and the effects were significantly countered by the protein tyrosine phosphatase (PTP) inhibitor orthovanadate (1 mM)."
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"The Src family kinase inhibitor PP2, but not the PTK-inactive analogue PP3, reversibly suppressed hERG channels, and the effect was significantly antagonized by the PTP inhibitor orthovanadate."
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"A Src family kinase inhibitor (PP2) and an EGFR kinase inhibitor (AG556) modulated hERG XREF_BIBR, but only the EGFR inhibitor regulated hEAG1 XREF_BIBR."
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