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USP37 inhibits SAMHD1. 7 / 7
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"Co-transfection of SAMHD1, SIVmac239, Vpx, and USP37 in HEK293T cells showed that USP37 inhibited the degradation of SAMHD1 by Vpx in a dose-dependent manner (Fig. 2A)."
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"Wenyan’s team also reported that deubiquitinase USP37 enhances the anti-HIV-2/SIV ability of the host restriction factor SAMHD1 [33], while USP3 inhibits HIV-1 replication via promoting APOBEC3G expression through both enzyme activity-dependent and -independent manners [34]."
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"USP37 reverses the degradation of SAMHD1 mediated by different subtypes of HIV-2/SIV."
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"We further determined that USP37 inhibits the degradation of SAMHD1 by HIV-2 Vpx (Fig. 3A)."
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"In this study, we demonstrated that deubiquitinase USP37 effectively inhibits the Vpx-mediated degradation and antiviral and anti-retrotransposition activities of SAMHD1 (Fig. 1, 2 and 8)."
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"As expected, the presence of USP37 reversed the degradation of SAMHD1 by HIV-2Rod, SIVsmm-L1V2, SIVsmm-L4, and SIVagm viruses, as shown by the positive control SIVmac239 (Fig. 3C)."
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"Therefore, USP37 reverses the degradation of SAMHD1 by different HIV-2/SIV subtypes."
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