IndraLab

Statements

CTNNB1 activates KCNH2. 6 / 6
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"According to chemiluminescence, beta-catenin may increase HERG channel abundance within the oocyte cell membrane."
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"As a result, expression of beta-catenin markedly upregulated HERG channel activity, an effect not sensitive to inhibition of transcription with actinomycin D (10 microM)."
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"The results reveal that the coexpression of beta-catenin leads to marked upregulation of HERG activity by enhancing the plasma membrane abundance of the channel protein."
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"Stimulation of HERG Channel Activity by beta-catenin."
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"Coexpression of beta-catenin Increased HERG Current."
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"Beta-catenin did not alter HERG channel kinetics but apparently increased the HERG protein abundance within the cell membrane."
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