IndraLab

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USP13 activates SIAH2. 5 / 8
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"Different forms of stress modulate these activities : hypoxia reduces USP13 expression enabling increased Siah2 activity, while cellular stress induces p38 activity and alters Siah localization, affec[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Conversely, inhibition of USP13 expression with corresponding shRNA decreases the stability of both Siah2 and its substrate Spry2."

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"Overexpression of USP13 increases Siah2 stability by attenuating its autodegradation."

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"Different forms of stress modulate these activities : hypoxia reduces USP13 expression enabling increased Siah2 activity, while cellular stress induces p38 activity and alters Siah localization, affecting its recognition and targeting of substrates 174."

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"In melanoma cells, USP13 attenuates the autodegradation of Siah2, a RING (really interesting new gene) finger family E3 ubiquitin ligase."