IndraLab

Statements

USP10 deubiquitinates SKP2. 3 / 3
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"USP10 deubiquitinates and stabilizes SKP2."
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"Increased USP10 led to the deubiquitination and stabilization of SKP2, causing BCR-ABL activation and promoting CML cells’ proliferation [85,86]."
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"Additionally, Liao and colleagues [XREF_BIBR] found that USP10 can promote leukemic cell proliferation by deubiquitinating and stabilizing the S-phase kinase associated protein 2 (SKP2) that acts as a co-regulator of BCR-ABL mediating its K63 linked ubiquitination and activation in CML cells [XREF_BIBR]."
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