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USP10 deubiquitinates SKP2. 11 / 12
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"Notably, the SKP2 is deubiquitinated by USP10, leading to suppressed osteogenic differentiation in BMSCs [134]."
40170748
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"Additionally, Liao and colleagues [XREF_BIBR] found that USP10 can promote leukemic cell proliferation by deubiquitinating and stabilizing the S-phase kinase associated protein 2 (SKP2) that acts as a co-regulator of BCR-ABL mediating its K63 linked ubiquitination and activation in CML cells [XREF_BIBR]."
32674429
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"USP10 deubiquitinates and stabilizes SKP2."
31044085
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"In cancer, USP10 decreased Skp2 ubiquitination, and we assessed the level of poly-ubiquitinated Skp2 using Co-IP assay (22)."
34599966
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"Increased USP10 led to the deubiquitination and stabilization of SKP2, causing BCR-ABL activation and promoting CML cells’ proliferation [85,86]."
35627217
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"On the other hand, USP10 (28) and USP13 (29) were reported to promote SKP2 deubiquitylation."
34425107
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"USP10 mediates the de-ubiquitination and stability of SKP2, while the latter can positively modulate the expression of BCR-ABL by regulating its K63-associated ubiquitination and activation."
38947742
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"We reported here that USP2 is a new deubiquitylase of SKP2 E3 ligase, which interestingly stabilized both SKP2 and SKP2 substrates.Two DUBs, USP10 and USP13, were previously reported to deubiquitylating SKP2."
34425107
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"In chronic myeloid leukemia cells, USP10 deubiquitylated SKP2 to stabilize SKP2."
34425107
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"Notably, Liao Y et al. reported that ubiquitin-specific peptidase 10 (USP10) could deubiquitinate SKP2 and promote SKP2 expression in chronic myeloid leukemia [21]."
37915040
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"Among them, SKP2 could be deubiquitinated by USP10 [40]."
37915040