IndraLab

Statements

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"For example, overexpression of USP13 blocks the AKT signaling pathway and suppresses tumor cell proliferation, invasion, and glycolysis by upregulating PTEN, while USP13 levels are downregulated in breast, bladder, and oral squamous tumors, in correlation with PTEN levels (Fig. 3)."
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"Downregulation of USP13 significantly attenuated the invasiveness of 143B cells, while overexpression of USP13 promoted the invasiveness of HOS cells by using the transwell invasion assay (Fig. 2a, b)."
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"Results suggested that overexpression of NF-kB p65 greatly increased the number of migrated and invaded cells, however knockdown of miR-130b/301b or restoration of USP13 rescued the increased cell invasion and migration caused by NF-kB activation."
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"USP13 knockdown in BC cells promoted their proliferation, invasion and migration."
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"Overexpression of miR-130b/301b or USP13 knockdown by shRNA delivery decreases USP13 expression, and further reduces PTEN protein expression and leads to enhancement of cell proliferation, invasion and migration."
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"Meanwhile, silencing of USP13 greatly enhanced proliferation, invasion and migration of the tested cells."
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