IndraLab

Statements

USP9X inhibits 3D. 4 / 4
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"Usp9x KD in all four PDX cell lines completely inhibited 3D colony growth (XREF_FIG, B and C) as compared to their respective scrambled controls."
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"Usp9x Inhibition Promotes 3D Colony Growth Independent of Mutant Kras Activity in Mouse Pancreatic Tumor Derived Cell Lines."
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"Although G9 treatment reduced human MIAPACA2 tumor burden in vivo, in mouse pancreatic cancer cell lines established from constitutive (8041) and doxycycline inducible (4668) KrasG12D and Tp53R172H mouse pancreatic tumors, Usp9x inhibition increased and sustained the 3D colony growth and showed no significant effect on tumor growth in 8041-xenografts."
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"Adding clinical relevance to our findings, Usp9x KD completely diminished 3D growth in patient derived PDX cells."
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