IndraLab
Statements
Mithramycin inhibits JUN. 2 / 2
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2
reach
"Thus, while mithramycin may still attenuate some p53-dependent intrinsic apoptotic program elements, including BH3-only molecules, downstream cell death proteases and caspase-independent mechanisms as well as c-Jun activation, the narrower nature of these effects and relatively modest role played by the caspase-dependent portion of this cascade will likely reduce the neuroprotective therapeutic effect of mithramycin in acute TBI."