IndraLab

Statements

Mithramycin inhibits JUN. 3 / 3
| 3
reach
"Thus, while mithramycin may still attenuate some p53-dependent intrinsic apoptotic program elements, including BH3-only molecules, downstream cell death proteases and caspase-independent mechanisms as well as c-Jun activation, the narrower nature of these effects and relatively modest role played by the caspase-dependent portion of this cascade will likely reduce the neuroprotective therapeutic effect of mithramycin in acute TBI."
32719328
reach
"Mithramycin reduced neuronal upregulation of BH3-only proteins and mitochondrial dysfunction, attenuated caspase-3/7 activation and caspase substrates ' cleavage, and limited c-Jun activation."
32719328
reach
"Mithramycin reduced neuronal upregulation of BH3-only proteins and mitochondrial dysfunction, attenuated caspase-3/7 activation and caspase substrates' cleavage, and limited c-Jun activation."
32719328