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EIF3F binds HNRNPK. 14 / 15
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"Considering that hnRNP K protects rRNA from degradation whereas eIF3f promotes this process, Wen et al. [XREF_BIBR] have proposed that eIF3f may interact with hnRNP K during apoptosis and promote rRNA degradation by interfering with its rRNA protective function."
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"We demonstrated that eIF3f directly interacts with hnRNP K. Under stress conditions, eIF3f dissociates hnRNP K from rRNA, thereby preventing it from protecting rRNA from degradation."
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No evidence text available
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No evidence text available
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"EIF3f directly interacts with hnRNP K."
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"Furthermore, recombinant eIF3f directly interacted with in vitro transcribed and translated hnRNP K ( xref )."
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"Previously, we showed that the Mov34/JAB_MPN domain of eIF3f was involved in protein-protein interaction xref ; in our current study, we showed that this domain also mediated the interaction between eIF3f and hnRNP K ( xref )."
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"These results suggested a direct interaction between eIF3f and hnRNP K."
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"We also showed that eIF3f interacted with hnRNP K during apoptosis."
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"During apoptosis, eIF3f might interact with heterogeneous nuclear ribonucleoprotein K blocking its RNA protective function."
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"During the apoptotic pathway, eIF3f is activated by CDK11p46, interacts with hnRNP K for RNA degradation, and is neutralized by Mss4."
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"Therefore, the interaction between eIF3f and hnRNP K may take place in stress granules or in other cytoplasmic foci, but not in P bodies."
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"Considering that hnRNP K protects rRNA from degradation whereas eIF3f promotes this process, Wen et al. [ xref ] have proposed that eIF3f may interact with hnRNP K during apoptosis and promote rRNA degradation by interfering with its rRNA protective function (Fig.  xref )."
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"We also showed that eIF3f interacted with hnRNP K during apoptosis."
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