IndraLab

Statements

USP7 activates F_actin. 2 / 2
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"Furthermore, knockout of one USP7 allele in HCT116 cells (USP7 +/-) resulted in impaired CI-M6PR recycling (XREF_FIG), decreased Arp2/3 localization to VPS35 positive endosomes (XREF_FIG and XREF_SUPPLEMENTARY), and decreased F-actin accumulation on VPS35 positive endosomes (XREF_FIG and XREF_SUPPLEMENTARY)."
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"While knockdown of USP7 and TRIM27 lowers F-actin production, TRIM27 mutants that are resistant to degradation accumulate F-actin, which is known to impair endosomal trafficking."
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