IndraLab

Statements

CTNNB1 phosphorylates CTNNB1 on S45. 4 / 4
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"Previous studies have verified that the beta-catenin destruction complex mediates sequential phosphorylation of beta-catenin at S45, T41, S37 and S33 for subsequent ubiquitination and proteasomal degradation and thereby maintains low baseline cytosolic levels of the protein in cancer cells XREF_BIBR, XREF_BIBR."
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"The destruction complex mediates sequential phosphorylation of beta-catenin at S45 by CK1alpha and then at T41, S37 and S33 by GSK3 and targets beta-catenin for the subsequent ubiquitination and proteasome degradation, and thereby maintaining low baseline cytosolic levels."
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"Once bound, GSK-3β phosphorylates β-catenin at Thr41, Ser33, and Ser37, and CK-1α phosphorylates β-catenin at Ser45."
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"Interestingly, Wnt5a was recently proposed to promote beta-catenin and E-cadherin association via CK1alpha mediated phosphorylation of beta-catenin at Ser45 but not Ser33 XREF_BIBR which supports a role for Ser45 phospho-beta-catenin in cell adhesion and also raises the possibility that localised phosphorylation at individual sites may lead to distinct functional outcomes."
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