IndraLab

Statements

BRCC3 inhibits CTNNB1. 4 / 4
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"After overexpression of BRCC36, VC was reduced and β-catenin pathway activation was inhibited (β-catenin phosphorylation decreased), suggesting that BRCC36 inhibited VC by inhibiting β-catenin pathway[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"BRCC36 inhibits VC via the Wnt/beta-catenin signalling pathway."
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"Moreover, β-catenin reporter (TOPFlash) assays revealed that BRCC36 overexpression decreased β-catenin transcriptional activity (Fig. 5I)."
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"Mechanistically, BRCC36 inhibited the Wnt/beta-catenin pathway by decreasing the K63-linked ubiquitination of beta-catenin."
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