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Crizotinib inhibits HCN4. 11 / 11
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"Crizotinib also slowed HCN4 activation and shifted the activation curve to the left towards more hyperpolarized potentials."
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"Calculation of the average time constant (Tau) of channel activation revealed that crizotinib resulted in slower HCN4 channel activation at test potentials> = -115 mV (*, washout vs. crizo, p < 0.05) (XREF_FIG)."
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"Calculation of the average time constant (Tau) of channel activation revealed that crizotinib resulted in slower HCN4 channel activation at test potentials ≥ −115 mV (*, washout vs. crizo, p < 0.05) (Fig. 4e)."
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"Crizotinib inhibits hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4) activity."
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"Crizotinib inhibits hyperpolarization activated cyclic nucleotide gated channel 4 (HCN4) activity."
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"The mechanism by which crizotinib inhibits HCN4 channels is beyond the scope of the current work but could involve either direct channel effects or indirect effects through crizotinib 's effects on multiple tyrosine kinases."
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"Although we found that crizotinib inhibits HCN4 channel activity, it is a non-selective channel inhibitor [19, 20]."
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"Furthermore, crizotinib significantly inhibited HCN4 channel activity, the major molecular determinant of I f."
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"Although we found that crizotinib inhibits HCN4 channel activity, it is a non selective channel inhibitor [XREF_BIBR, XREF_BIBR]."
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"Furthermore, crizotinib significantly inhibited HCN4 channel activity, the major molecular determinant of I ."
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"Crizotinib also slowed HCN4 activation and shifted the activation curve to the left towards more hyperpolarized potentials."
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