IndraLab

Statements


| 5

reach
"Furthermore, crizotinib significantly inhibited HCN4 channel activity, the major molecular determinant of I ."

reach
"Crizotinib also slowed HCN4 activation and shifted the activation curve to the left towards more hyperpolarized potentials."

reach
"Crizotinib inhibits hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4) activity."

reach
"Calculation of the average time constant (Tau) of channel activation revealed that crizotinib resulted in slower HCN4 channel activation at test potentials ≥ −115 mV (*, washout vs. crizo, p < 0.05) (Fig. 4e)."

reach
"Although we found that crizotinib inhibits HCN4 channel activity, it is a non-selective channel inhibitor [19, 20]."