IndraLab

Statements



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"ALZET osmotic pumps (Model 1004; Durect Corporation, Cupertino, CA, USA) were loaded with the BK channel activator isopimaric acid (ISO groups; 1 mM, 100 μl, solved in DMSO) or DMSO only (vehicle grou[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"We set out to examine whether cognition in 3xTg mice would be improved by chronically injecting the BK channel activator isopimaric acid into the ventricle."

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"Since we wondered whether these two phenomena are related, induction of hippocampal LTP was attempted under application of the BK channel activator isopimaric acid (Iso; 3.3 μM) in slices from 3xTg mi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Although this study revealed that the suppression of BK channel activity by Aβ 1–42 was reversed in vitro by the BK channel activator isopimaric acid ( Yamamoto et al., 2011 ), its behavioral signific[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"We then examined the effect of BK channel activator isopimaric acid."

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"In reverse, facilitation of BK channels by the BK channel activator isopimaric acid normalizes the spike width."