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USP30 inhibits MFN2. 2 / 2

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"Inhibition of USP30 leads to increased non-degradative ubiquitination of Mfn1/2, thereby enhancing the activity of Mfn1 and Mfn2, and promoting mitochondrial fusion [ 23 ]."

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"S3 induced inhibition of USP30, a mitochondrial localized deubiquitinase, increased the ubiqutinylation of MFN1 and MFN2 without affecting their protein levels."

25818167

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IndraLab

Statements

USP30 inhibits MFN2. 2 / 2

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