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PF inhibits RELA. 4 / 4
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"The results showed that PF inhibited CD25、CD69 and NF-κB p65 on T lymphocytes in a dose-dependent manner.The effect of PF on IFN-γ and IL-4 production by T lymphocytes were examined."
33965879
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"The results (Fig. 6) demonstrated that 3 μM, 6 μM and 12 μM of PF decreased the concentration of p65 in the nucleus in LPS‑stimulated RAW 264.7 macrophages (P < 0.05, P < 0.05, P < 0.001)."
37936108
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"Our results showed that PF could inhibit activation of NF-kappaBp65, whereas NF-kappaBp65 may contribute to inflammatory related complex cellular pathways, and it is also one of the mechanisms of its therapeutic effect on RA (XREF_FIG)."
29887769
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"Taken together, our study reveals a mechanism underlying TNF-alpha-induced cell apoptosis : PF could inhibit the activity of NF-kappaBp65 and apoptosis of L929 cells induced by TNF-alpha, suggesting that PF may play a role in the treatment of RA through the antagonism of TNF-alpha pathway."
29887769