IndraLab

Statements

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"Therefore, it can be speculated that USP4 promotes brain metastasis of LUAD cells by stabilizing the β-catenin protein74."
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"Mechanistically, USP4 can directly bind to the TRAF domain to inhibit TRAF2/TRAF6 activity through deubiquitination in an activity-dependent manner and negatively regulate IL-1β and TNF-α-induced NF-κB activation, thereby inhibiting lung cancer metastasis (46)."
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"Using bioluminescence imaging, we found that knockdown of USP4 suppressed brain metastasis in vivo and significantly increased overall survival and brain metastasis-free survival."
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"USP4 accelerates the growth, invasion, and metastasis of colorectal cancer [XREF_BIBR, XREF_BIBR]."
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"In addition , USP4 reportedly mediates cell proliferation , survival and metastasis ( 32 , 33 ) ."
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"53 USP4 interacts with cyclophilin A and TGF-beta receptor type I and promotes the progression and metastasis of HCC ."
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"USP4 promotes proliferation and metastasis in human lung adenocarcinoma."
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"Studies have shown that USP4 plays an important role in rectal cancer bladder cancer melanoma The high expression of USP4 in liver cancer and cervical squamous cell carcinoma implies that USP4 may be a potential oncogene, and it has been confirmed that the abnormal expression of USP4 promotes the occurrence, development, invasion and metastasis of rectal cancer ."
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"In vivo, we also found that USP4 knockdown obviously blocked HCC cell metastasis."
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"Hematoxylin-eosin (H&E) staining was carried out to assess lung nodules in mice based on the tissue structure and nuclei, and the staining results also showed that USP4 knockdown inhibited the lung metastasis of KYSE150 cells, while USP4 overexpression in KYSE180 cells promoted lung metastasis in vivo (Fig. 3G, H)."
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"Taken together, our results elucidate that USP4 is highly expressed in HCC and promotes the tumor invasion and metastasis, the underlying mechanism is that USP4 directly interacts with and deubiquitinates TGFR-1 to increase TGF-beta signaling Induced EMT."
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"53 USP4 interacts with cyclophilin A and TGF‐β receptor type I and promotes the progression and metastasis of HCC."
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"Finally, we investigated the mechanism by which USP4 promotes growth and metastasis in ESCC cells."
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"Further, we investigated the mechanism by which USP4 promotes growth and metastasis in HCC cells."
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"USP4 can promote TGF-beta-induced invasion and metastasis of breast cancer cells in a zebrafish xenograft model."
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"In contrast, depletion of USP4 significantly inhibited proliferation, migration, and invasion abilities in vitro and suppressed tumor growth and metastasis in vivo."
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"USP4 can serve as a double-edged sword in tumor progression because it functions as a tumor suppressor in lung cancer by indirectly circumventing stemness [56], while USP4 promotes TNBC metastasis by enhancing TGF-β signaling and inducing the suppressive activity of Tregs [87, 119]."
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"As we have discussed above, USP4 can target the TGF-beta type I receptor and promote invasion and metastasis of breast cancer and high USP15 expression correlated with enhanced pSmad2 expression in ti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Luminescence imaging experiments indicated that knockdown of USP4 suppressed brain metastasis in vivo and promoted the overall survival and brain metastasis-free survival."
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"Inhibition of USP4 would be expected to inhibit the invasion and metastasis of breast cancer and drugs that target USP15 could reduce the oncogenic potential of glioblastomas."
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"Moreover, USP4 is recently showed to enhance EMT and metastasis by stabilizing TbetaRI [XREF_BIBR]."
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"For example, USP4 drives breast cancer cell invasion via Relaxin/TGF-β1/Smad2/MMP-9 (matrix metallopeptidase 9) signalling [93] and promotes hepatocellular carcinoma metastasis by enhancing TGF-β sign[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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