IndraLab

Statements

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"As we have discussed above, USP4 can target the TGF-beta type I receptor and promote invasion and metastasis of breast cancer and high USP15 expression correlated with enhanced pSmad2 expression in ti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP4 accelerates the growth, invasion, and metastasis of colorectal cancer [XREF_BIBR, XREF_BIBR]."
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"Therefore, it can be speculated that USP4 promotes brain metastasis of LUAD cells by stabilizing the β-catenin protein74."
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"Luminescence imaging experiments indicated that knockdown of USP4 suppressed brain metastasis in vivo and promoted the overall survival and brain metastasis-free survival."
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"53 USP4 interacts with cyclophilin A and TGF-beta receptor type I and promotes the progression and metastasis of HCC ."
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"USP4 can promote TGF-beta-induced invasion and metastasis of breast cancer cells in a zebrafish xenograft model."
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"53 USP4 interacts with cyclophilin A and TGF‐β receptor type I and promotes the progression and metastasis of HCC."
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"Using bioluminescence imaging, we found that knockdown of USP4 suppressed brain metastasis in vivo and significantly increased overall survival and brain metastasis-free survival."
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"In addition , USP4 reportedly mediates cell proliferation , survival and metastasis ( 32 , 33 ) ."
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"Moreover, USP4 is recently showed to enhance EMT and metastasis by stabilizing TbetaRI [XREF_BIBR]."
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"In vivo, we also found that USP4 knockdown obviously blocked HCC cell metastasis."
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"Inhibition of USP4 would be expected to inhibit the invasion and metastasis of breast cancer and drugs that target USP15 could reduce the oncogenic potential of glioblastomas."
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"Further, we investigated the mechanism by which USP4 promotes growth and metastasis in HCC cells."
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"Taken together, our results elucidate that USP4 is highly expressed in HCC and promotes the tumor invasion and metastasis, the underlying mechanism is that USP4 directly interacts with and deubiquitinates TGFR-1 to increase TGF-beta signaling Induced EMT."
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