IndraLab

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USP4 binds IRF4. 15 / 18
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reach
"To conclude, this study indicated that USP4 interacts with and deubiquitinates IRF4, and also stabilizes IRF4 protein and promotes IRF4 function to facilitate IL-4 expression in Th2 cells, which may be associated with the pathological process of RHD."
28791349
sparser
"These results demonstrated that USP4 and IRF4 interact directly with each other."
28791349
sparser
"The association of USP4 and IRF4 was corroborated by reverse co-immunoprecipitation experiment using the anti-Myc antibody to immunoprecipitate IRF4 and anti-Ha to detect the associated Ha-IRF4 by western blot analysis ( xref )."
28791349
sparser
"We found that immunoprecipitation of USP4 using the anti-USP4 antibody resulted in the co-immunoprecipitation of Myc-IRF4 as detected by immunoblotting with anti-Myc antibodies, indicating that USP4 interacts with IRF4 in Th2 cells ( xref )."
28791349
sparser
"In this study, we not only found an interaction between USP4 and IRF4, but also proved the effect of USP4 on the stabilization and deubiquitination of IRF4."
28791349
reach
"Here, the interaction between USP4 and IRF4 were analyzed by co-immunoprecipitation assay."
28791349
reach
"Our results validated the interaction between USP4 and IRF4, and effects of USP4 on stabilization and deubiquitination of IRF4 were also found."
28791349
reach
"On the whole, our data indicate that USP4 interacts with and deubiquitinates IRF4, and also stabilizes IRF4 protein and promotes IRF4 function to facilitate IL-4 expression in Th2 cells, which may be related to the pathological process of RHD."
28791349
reach
"In this study, we not only found an interaction between USP4 and IRF4, but also proved the effect of USP4 on the stabilization and deubiquitination of IRF4."
28791349
reach
"Interaction between USP4 and IRF4."
28791349
reach
"We found that immunoprecipitation of USP4 using the anti-USP4 antibody resulted in the co-immunoprecipitation of Myc-IRF4 as detected by immunoblotting with anti-Myc antibodies, indicating that USP4 interacts with IRF4 in Th2 cells (XREF_FIG)."
28791349
sparser
"Here, the interaction between USP4 and IRF4 were analyzed by co-immunoprecipitation assay."
28791349
sparser
"Our results validated the interaction between USP4 and IRF4, and effects of USP4 on stabilization and deubiquitination of IRF4 were also found."
28791349
sparser
"Interaction between USP4 and IRF4."
28791349
sparser
"USP4 interacts with IRF4 and deubiquitinates K48- and K63-linked polyubiquitination, thereby stabilizing IRF4."
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