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UCHL1 increases the amount of glutathione. 3 / 3
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"The UCHL1 dependent increase in the intracellular GSH levels was significantly suppressed by silencing the expression of a key molecule of the pentose phosphate pathway, the glucose-6-phosphate dehydrogenase X linked (G6pdx) gene XREF_BIBR, XREF_BIBR."
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"By increasing intracellular glutathione levels, UCHL1 mediates HIF-1-dependent changes in the antioxidant cellular status that promotes resistance to radiotherapy [29] ."
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"The UCHL1 mediated reprogramming elevated intracellular GSH levels, and consequently induced a radioresistant phenotype in a HIF-1-dependent manner."
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