IndraLab

Statements

SUMO1 activates ATXN3. 4 / 5
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"Interestingly, SUMO-1 overexpression enhanced the co-localization of ataxin-3 and autophagy marker LC3 without increasing LC3 puncta formation suggesting that SUMO-1 is involved in the substrate recruitment rather than the induction of autophagy."
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"In addition, we further confirmed SUMO-1 modification decreased the degradation and enhanced the stability of mutant-type ataxin-3 by chase assay."
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"By contrast, SUMO-1 coexpression significantly enhanced the colocalization of LC3 and ataxin-3 signals (highlighted by arrows) (XREF_FIG, upper panels)."
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"In addition to the SUMO dependent recruitment of ATXN3, free SUMO1 can also stimulate ATXN3 DUB activity against Ub-K63 chain in vitro."
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