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"Moreover, an experimental study of central administration of interleukin-1β in rats demonstrated that interleukin-1β may stimulate synthesis and release of hypothalamic histamine at presynaptic terminals by activation of histidine decarboxylase (a histamine-synthesizing enzyme) and thus facilitate the degradation of extracellular histamine by the activation of histamine-N-methyltransferase (a degrading enzyme). xref These results indicate that interleukin-1β activates neural histamine turnover in the hypothalamus."