IndraLab

Statements

Lactate inhibits NLRP3. 6 / 6
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"Further, lactate suppresses the induction of the NLRP3 inflammasome and IL1beta via GPR81 activation, regulates TLR activation via interactions with arrestin B2 downstream of GPR81, and protects against inflammatory injury in pancreatitis and hepatitis models through GPR81 signaling."
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"In macrophages and monocytes, increasing concentrations of lactate reduced TLR4 mediated induction of Il1B, Nlrp3, and Casp1; activation of NFkappaB; release of IL1beta; and cleavage of CASP1."
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"Inhibition of lactate dehydrogenase with GSK2837808A reduced lactate production and activity of the NLRP3 inflammasome regulator, phosphorylated protein kinase R (PKR), but did not reduce the common trigger of NLRP3 inflammasome, potassium efflux, or reactive oxygen species (ROS) production."
33854503
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"After gavage of apigenin, apigenin can significantly reduce the level of lactate dehydrogenase (LDH) in liver tissue ignited by HFD and reduce the levels of NLRP3 (NOD-like receptor family pyrin domain containing 3), the N-terminal domain of GSDMD (GSDMD-N), cleaved-caspase 1, cathepsin B (CTSB), interleukin-1β (IL-1β) and interleukin-18 (IL-18) protein expression and the colocalization of NLRP3 and CTSB and increase the level of lysosomal associated membrane protein-1 (LAMP-1) protein expression, thus alleviating cell pyroptosis."
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"Inhibition of pyruvate oxidation reprogrammed pyruvate metabolism from mitochondrial pyruvate driven respiration to cytoplasmic lactic acid fermentation and further activates the regulator of NLRP3 inflammasome activation, lactate dependent PKR phosphorylation."
33854503
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"Invitro experiments, by isolating the pancreatic acinar cells (PACs) from mice, we found that Indo significantly reduced lactate dehydrogenase (LDH) excretion, increased the cell activity, and inhibited the NLRP3 inflammasome pathway of PACs."
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