IndraLab

Statements

CCL5 binds CD44. 16 / 17
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"Such pretreatment also abolishes the binding of RANTES to CD44."
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"As introduced before, CCL5 is an extremely powerful chemoattractant with a physiologic role in recruiting immune cells in inflammatory or allergic circumstances [26] CCL5 binds with high affinity to its main receptor CCR5, but also to CCR1, -3, -4, CD44 and GPR75."
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"Moreover, the binding of RANTES and CCL5 to SDC-1, SDC-4 and CD44 on HeLa cells was dependent on GAGs [10]."
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"CCL5 binds with high affinity to its receptor CCR5, but it also binds CCR1, CCR3, CCR4 [27,28], CD44 [27,29], and GPR75 [30]."
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"Contribution of keratinocytes overexpressing PA28γ to CD4+ T‐cell differentiation via the CCL5‐CD44 pathway in OLP."
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"It has been reported that binding of RANTES to CD44 can lead to p44/p42 MAPK signaling and improved HIV infection ( xref ), and a similar mechanism may play a role in our observations."
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"We observed no further reduction of cell proliferation in Ccl5 KD cells following Cd44 knockdown, suggesting that this pro survival pathway is specific to the interaction between Ccl5 and CD44, and is not regulated by other CD44 ligands."
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"In this study, we found that the interaction between Ccl5 and CD44 enhances cell survival in M-GBM cells."
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"In our studies, ERK activity in M-GBM cells was not reduced following Ccl5 KD (data not shown), suggesting that a distinct signaling pathway is activated following Ccl5 binding to CD44 in M-GBM cells."
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"Moreover, in these conditions, no RANTES bound CD44 was detected, which demonstrates that RANTES binding to CD44 expressed on MDM is GAGs-dependent (, lane 9)."
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"We observed no further reduction of cell proliferation in Ccl5 KD cells following Cd44 knockdown (Figure xref ), suggesting that this pro-survival pathway is specific to the interaction between Ccl5 and CD44, and is not regulated by other CD44 ligands."
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"When we focused on the top-ranked interaction pairs, we found seven source-target gene pairs from CCIDB (i.e. FGL2_FCGR3A, TINAGL1_ITGB1, MDK_LRP1, THY1_ITGB2, CCL5-CD44, SRGN_CD44 and CXCL12_CXCR4) that showed intracellular communication across various cell types, including T cells, myeloid cells, endothelial cells and cancer epithelial cells ( xref )."
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"Subsequently, CCL4 induces microglia to secrete CCL5, which binds to CD44 and activates downstream pathways such as AKT/GSK3β/CREB to inhibit apoptosis and maintain the growth of low-grade glioma (LGG) cells. xref In addition, microglia also convey information to cancer cells by releasing miR-124-enriched small extracellular vesicles (sEVs), which reprogram tumor metabolism by reducing the release of lactate, nitric oxide (NO) and Glu."
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"In this study, we found that the interaction between Ccl5 and CD44 enhances cell survival in M-GBM cells."
28380429
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"In our studies, ERK activity in M-GBM cells was not reduced following Ccl5 KD (data not shown), suggesting that a distinct signaling pathway is activated following Ccl5 binding to CD44 in M-GBM cells."
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"RANTES binding to CD44 expressed on HeLa cells has been recently demonstrated ."
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