IndraLab

Statements

CCL5 binds CD44. 13 / 14
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"We observed no further reduction of cell proliferation in Ccl5 KD cells following Cd44 knockdown (Figure xref ), suggesting that this pro-survival pathway is specific to the interaction between Ccl5 and CD44, and is not regulated by other CD44 ligands."
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"RANTES binding to CD44 expressed on HeLa cells has been recently demonstrated ."
14637022
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"Glycosaminidases pre-treatment of the monocyte derived-macrophages strongly decreases the binding of RANTES to syndecan-1 and syndecan-4 and also to CCR5, and abolishes RANTES binding to CD44."
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"In our studies, ERK activity in M-GBM cells was not reduced following Ccl5 KD (data not shown), suggesting that a distinct signaling pathway is activated following Ccl5 binding to CD44 in M-GBM cells."
28380429
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"Such pretreatment also abolishes the binding of RANTES to CD44."
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"We observed no further reduction of cell proliferation in Ccl5 KD cells following Cd44 knockdown, suggesting that this pro survival pathway is specific to the interaction between Ccl5 and CD44, and is not regulated by other CD44 ligands."
28380429
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"In this study, we found that the interaction between Ccl5 and CD44 enhances cell survival in M-GBM cells."
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"In this study, we found that the interaction between Ccl5 and CD44 enhances cell survival in M-GBM cells."
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"CCL5 binds with high affinity to its receptor CCR5, but it also binds CCR1, CCR3, CCR4 [27,28], CD44 [27,29], and GPR75 [30]."
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"Moreover, in these conditions, no RANTES bound CD44 was detected, which demonstrates that RANTES binding to CD44 expressed on MDM is GAGs-dependent (, lane 9)."
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"In our studies, ERK activity in M-GBM cells was not reduced following Ccl5 KD (data not shown), suggesting that a distinct signaling pathway is activated following Ccl5 binding to CD44 in M-GBM cells."
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"It has been reported that binding of RANTES to CD44 can lead to p44/p42 MAPK signaling and improved HIV infection ( xref ), and a similar mechanism may play a role in our observations."
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"Moreover, the binding of RANTES and CCL5 to SDC-1, SDC-4 and CD44 on HeLa cells was dependent on GAGs [10]."
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