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USP18 activates CSF1R. 3 / 3
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"It revealed that degradation of CSF1R was faster in BMDMs from Usp18 mice than in control cells, indicating that USP18 deletion enhanced the process of CSF1R degradation (Figure 6A)."
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"In our current study, we revealed another mechanism of CSF1R regulation mediated by USP18 and NEDD4.Reduction of CSF1R on cell membranes has been reported by shedding with TNF-α-converting enzyme TACE and γ-secretase and by CSF1 or Toll-like receptor (TLR) agonist-stimulated internalization and lysozyme degradation."
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"This study, led by Miyauchi et al., found that the reduction of USP18 enhances the proteasomal degradation of colony stimulating factor 1 receptor (CSF1R) mediated by ubiquitin conjugating enzyme E2 D1 (UBCH5) and neural precursor cell expressed developmentally downregulated 4 E3 ubiquitin protein ligase (NEDD4)."
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