IndraLab

Statements

USP26 inhibits UIMC1. 3 / 3
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reach
"We reasoned that USP26 and USP37 may antagonize the RAP80 dependent sequestration of BRCA1 by removing RNF8 and RNF168 mediated ubiquitylation and thereby promote HR."
26101254
reach
"USP26 and USP37 have additionally been shown to impair accumulation of RAP80 and BRCA1 [154]."
32708614
reach
"Together, these results suggest that USP26 and USP37 promote the BRCA1 dependent loading of PALB2 and RAD51 by counteracting the repressive impact of RAP80 dependent BRCA1 sequestration and RAP80 dependent inhibition of end-resection during HR."
26101254