IndraLab

Statements

USP15 inhibits TPPP. 4 / 4
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"Remarkably, the band intensity of p24 degraded by USP15 was visibly weaker (XREF_FIG vs A), when the cells were treated with Bafilomycin A1."
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"These data establish that USP15 mediated p24 degradation is achieved via both endosomal and proteosomal degradation."
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"However, the observed degradation of p24 by USP15 was effectively abrogated, when the transfected cells were treated with MG132 (XREF_FIG), indicating that the proteosomal degradation pathway plays a key role in USP15- mediated degradation of Gag protein."
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"In corroboration, the observed degradation of p24 by USP15 (XREF_FIG) was thoroughly abrogated, when the transfected cells were treated with MG132 (XREF_FIG), indicating that the proteosomal degradation pathway acts on the USP15 mediated degradation of Gag protein."
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