IndraLab

"Thus, our analysis and experimental validation across mouse and human mesothelioma cells clearly identify a set of genes regulated via the BAP1-PRC2 axis."

"BAP1 does not interact with PRC2 proteins ( xref )."

"ASXL1 functions in transcriptional repression through its interaction with PRC2 and BAP1. xref BCORL1 is a transcriptional co-repressor that interacts with PCGF1, a core complex of the PRC1.1 complex. xref The RUNX1-CBF-b heterodimer mediates transcription by binding to RUNX sites, but also represses transcription by interacting and recruiting BMI1 of the PRC1 complex to target sites. xref IKZF1 regulates transcription by interacting with repressive epigenetic complexes such as HDAC1, HDAC2, CHD3, CHD4, and SWI/SNF complex, and also recruits PRC2 to target gene loci in T cells. xref Thus, while the commonly mutated genes in CML have their own exclusive roles in transcriptional regulation, they also share a striking commonality as modulators of the PRC."

"In addition, BAP1 mutations in ccRCC tumors were associated with downregulated expression of target genes of polycomb repressive complex 2 (PRC2) [ xref ] ( xref )."