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Gallic acid inhibits NLRP3. 15 / 15
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"Furthermore, the present study demonstrates that GA lowered the contents of IL-1β and IL-18 in serum and colon tissues of BALB/c mice, elevated by DSS (Figure 2), and downregulated the protein and mRNA expressions of the NLRP3 pathway in the colon tissue (Figures 3, 4), demonstrating that GA inhibited the activation of the NLRP3 inflammasome."
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"It exerts its therapeutic effect on GA by modulating the NF-κB signaling pathway, suppressing the activation of the NLRP3 inflammasome, and activating the Nrf2 pathway."
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"Additionally, gallic acid blocked NLRP3 inflammasome activation and inhibited the subsequent activation of caspase-1 and secretion of IL-1beta."
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"In addition, GA supplementation in HFD inhibited the upregulation of NLRP3, ASC, caspase-1, IL-1β, IL-18 and GSDME."
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"GA also inhibited the activity of Nox4/NLRP3 pathway, which suppressed cell apoptosis and inflammatory response of HRECs under high glucose conditions [157]."
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"123 In the same way, Gallic acid could eliminate the inflammatory cytokines (such as IL-6 and IL-1β) and targets of the inflammasome (including Caspase-1 and NLRP3) induced by Pg-LPS in human ligament periodontal cells."
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"Besides, GA abolished Pg-LPS-induced inflammation cytokines (il-6, il-1β) and inflammasome targets (Caspase-1, NLRP3)."
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"GA can inhibit Nox4/NLRP3 pathway activity, thus inhibit HRECS cell apoptosis and inflammation under high glucose condition."
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"HSP90 is also essential for the activation of NLRP3 inflammasome, and geldanamycin (GA), a specific inhibitor of HSP90, blocks NLRP3 inflammasome activation and helps ameliorate NLRP3 inflammasome mediated diseases 35."
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"NOX4/NLRP3 pathway activation in HRECs was significantly inhibited by 15 µM of GA under high glucose conditions."
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"At the cellular level, GA suppressed ox-LDL-induced pyroptosis of HAECs by reducing reactive oxygen species (ROS) levels and inhibiting NLRP3 inflammasome."
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"Lin et al. found that gallic acid inhibited the assembly of the NLRP3 inflammasome by enhancing antioxidant capacity, and inhibited the subsequent activation of caspase-1 and pyroptosis [ 46 ]."
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"In a co-culture model of intestinal inflammation, gallic acid inhibits IL-1β production and activation of NLRP3 inflammasome ( Luzardo-Ocampo et al., 2020 )."
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"Our data demonstrated that GA inhibited the Nlrp3 signaling pathway to prevent its activation, because Cle-caspase1 had no significant change in Nlrp3-deficient macrophages stimulated with LPS ( Fig. [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"GA can inhibit the apoptosis and inflammation of HRECs under high glucose conditions by inhibiting the activity of the NOX4/NLRP3 pathway."
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