IndraLab

Statements

STX1A binds CACNA1B and DPYSL2. 2 / 2
| 2
sparser
"We propose that CNRP1 uncouples CRMP2’s interactions with Cav2.2 and syntaxin 1A, resulting in Cav2.2 relocalization away from the plasma membrane; decreased synaptic vesicle docking to the Ca 2+ channel; and consequently, decreased CGRP release."
28767512
sparser
"However, loss of neurofibromin, as observed in NF1 patients, results in disinhibition of the tripartite CRMP2-Cav2.2-syntaxin 1A interaction, therefore permitting increased N-type Ca 2+ currents and CGRP release."
30364788