IndraLab

Statements

NADase activates KCNMA1. 9 / 9
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"Since SLO stability is supported by the production of NADase (whether enzymatically active or inactive), we investigated whether NADase stability is reciprocally supported by the presence of SLO."
28900022
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"Reduction of SLO concentration, in the absence of NADase, would reduce SLO mediated resistance to GAS killing by phagocytes and epithelial cells."
28900022
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"Together, these earlier observations led us to propose that NADase may enhance the cytotoxic effects of SLO even in the presence of polymorphisms that attenuate enzymatic activity."
28900022
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"Anthrax toxin mediated delivery of NADase in an amount comparable to that observed during in vitro infection with live GAS rescued the defective intracellular survival of NADase deficient GAS and increased the survival of SLO deficient GAS."
26938870
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"The NADase translocation domain and SLO appear to recognize similar glycan structures on the cell surface, which may be one mechanism through which NADase enhances SLO pore-forming activity during infection."
34694903
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"This observation is consistent with a previous report that NADase activity augments the hemolytic activity and cytotoxicity of SLO."
28034602
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"NADase augments SLO mediated cytotoxicity by depleting cellular energy stores."
25227466
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"12 Furthermore, the NADase activity of SPN augments the cytotoxicity and the hemolytic activity of SLO."
28034602
reach
"Intracellular delivery of NADase enhances survival of SLO deficient GAS."
26938870