IndraLab

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Modified USP37 increases the amount of Snail1 protein. 2 / 2
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"Overexpression of USP37 in SGC7901-shRNA cells restores Snail1 protein levels, which shows that the USP37-Snail1 axis plays a vital role in PLAGL2 mediated Snail1 stabilization."

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"As shown in Figure XREF_FIG D and XREF_SUPPLEMENTARY A, depletion of USP37 in SGC7901 and HEK293T cells significantly reduced Snail1 protein expression, whereas enhanced USP37 expression in AGS and HEK293T cells dramatically upregulated the Snail1 protein levels."