IndraLab

Statements

UCHL5 inhibits Proteasome. 4 / 5
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"For elderly patients with reduced proteostasis capacity, high UCHL5 levels may further inhibit proteasome activity, thereby promoting apoptosis in cancer cells."
29474458
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"UCH-L5 can suppress proteasome mediated degradation via the disassembly of distal polyubiquitin moieties."
24271000
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"In particular, deubiquitinating enzymes Uch37 and Usp14, being physically associated with the proteasome, may suppress proteasome activity through deubiquitinating a subset of ubiquitinated substrates, once the substrate is docked at the proteasome."
23994620
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"It is possible that excess UCHL5 expression substantially impairs proteasome activity, causing abnormal accumulation of proteasomal substrates, and harming tumor cells."
29474458