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CPKC activates KCNQ1. 3 / 3
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"Collectively, we show that Ang II stimulated PKCepsilon activation promoted the endocytosis of KCNQ1 and KCNE1 channel and inhibited the channel forward transport to the plasma membrane, while PMA stimulated cPKC activation only promoted the internalization of KCNQ1 and KCNE1 channel."
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"Our data shows that alpha 1 -AR - cPKC signaling activates the KCNQ1 and KCNE1 channel by shifting the voltage dependence of channel activation via phosphorylation of ancillary subunit KCNE1 at Ser102."
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"Rosuvastatin treatment, in contrast to fluvastatin did not affect cPKC-mediated internalization of KCNQ1 (Fig. 3b)."
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