IndraLab

Statements

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"The results showed that NO induced the degradation of IkappaB-alpha in the cytosol and translocation of NF-kappaB to the nucleus in HEI-OC1 cells."
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"Although we observed a potent inhibition of NO on IkappaBalpha degradation by purified proteasome, only partial inhibition of cellular IkappaBalpha degradation by NO was measured."
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"To determine the mechanism of Resveratrol mediated inhibition of apoptosis and NF-kappaB activation, chondrocytes were treated with SNP (1 mM) and Resveratrol (20 muM) for 24 h. Western blotting showed that NO induced IkappaB-alpha degradation, Pro-caspase-3 and caspase-3 expression, and these effects were abrogated by Resveratrol (XREF_FIG A)."
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