IndraLab

Statements

OTUB1 inhibits autophagy. 5 / 5
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"Relevance of OTUB1 deletion-induced autophagy activation in ferroptosis."
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"These results imply that autophagy activation caused by OTUB1 loss may cause ferroptosis."
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"We investigated the protein interactome of OTUB1 using immunoprecipitation coupled with mass spectrometry (IP/MS) in order to clarify the underlying mechanism by which OTUB1 knockdown triggers autophagy during ferroptosis."
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"We observed that OTUB1 silencing enhances autophagosome production and augments autophagy flux, thereby revealing a potential mechanistic link between OTUB1 and ferroptosis promotion."
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"To further elucidate the underlying mechanism by which OTUB1 silencing activates autophagy during ferroptosis, we conducted IP/MS analyses and identified a direct interaction between the OTUB1 and P62 proteins in C2C12 cells."
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