IndraLab

Statements

USP7 activates MYCN. 4 / 8
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"The removal of ubiquitin and subsequent stabilization of N-Myc suggests HAUSP prevents N-Myc degradation."
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"HAUSP interacts with N-Myc, and HAUSP expression induces deubiquitination and subsequent stabilization of N-Myc."
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"Notably, HAUSP was able to stabilize both N-Myc Delta382 -- 464 and N-Myc Delta346 -- 464 but not N-Myc Delta281 -- 464 in the same assay (XREF_FIG), suggesting that direct interaction is required for HAUSP mediated stabilization of N-Myc."
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"Therefore, we reasoned that ablation of HAUSP may drive N-Myc proteolysis."
27618649