IndraLab

Statements

USP28 increases the amount of CLASP1. 4 / 4
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"USP28 positively regulates MAST1 protein levels."
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"Together, these results suggest that USP28 positively regulates MAST1 protein levels."
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"Together, these results indicate that loss of USP28 decreased MAST1 protein level and suppressed tumor growth upon cisplatin treatment."
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"Furthermore, we showed that the loss of USP28 downregulates MAST1 protein level and sensitizes cells for cisplatin toxicity during tumor growth, leading to reduced tumor size, volume and weight.In conclusion, our study demonstrates that USP28 could enhance MAST1-driven cisplatin resistance by stabilizing MAST1 protein level in cancer."
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