IndraLab

Statements

Modified BAP1 increases the amount of ITPR3. 3 / 3
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"Consequently, heterozygous loss of BAP1 leads to decreased IP3R3 levels and resistance to apoptotic stimuli, as demonstrated in human fibroblasts or mesothelial cells derived from mutant BAP1 +/- carriers and in mesothelioma cell lines 174."
29242641
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"Loss of BAP1 therefore leads to loss of ITPR3, which in turn reduces apoptotic mitochondrial calcium signals [XREF_BIBR]."
31315892
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"Reduced levels of BAP1 in BAP1 +/- carriers caused reduction of both IP3R3 levels and Ca 2+ flux, preventing BAP1 +/- cells that had accumulated DNA damage from executing apoptosis."
28614305