IndraLab

Statements

USP7 inhibits USP22. 5 / 5
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"Taken together, our findings demonstrate that USP7 inhibition can dramatically upregulate USP22 in cancer cells; and targeting USP7 and USP22 may represent a more effective approach for targeted cancer therapy, which warrants further study."
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"In this study, through screening known USPs inhibitors against USP22 DUB complex, we, for the first time, surprisedly found that pharmaceutical inhibition or knockdown of USP7 can dramatically upregulate USP22 protein in cancer cells independent of these cells’ p53 status."
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"To further validate the specificity of the upregulation, we made siRNA-mediated USP7-knockdown (USP7-Kd) in A549 and H1299 lung cancer cells and found that USP7-Kd also markedly upregulates USP22 (Fig. 1D) in both cancer cell lines."
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"Upregulation of USP22 by USP7 inhibition through SP1 degradation."
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"Inhibition of USP7 upregulates USP22 and activates its downstream cancer-related signaling pathways in human cancer cells."
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