IndraLab

Statements

CAPN activates ATXN3. 11 / 12
| 11
reach
"This phenotype could be abolished by calpain inhibition, indicating a key role of calpain in ATXN3 aggregation."
22888453
reach
"Calpain cleavage sites have been identified along the ataxin-3 protein, supporting the hypothesis of calpain mediated ataxin-3 proteolysis."
32765211
reach
"Calpain inhibition reduces ataxin-3 cleavage alleviating neuropathology and motor impairments in mouse models of Machado-Joseph disease."
24817574
reach
"It was discovered that inhibition of Ca 2+ -dependent protease calpain suppressed aggregation of polyglutamine expanded Atxn3 in transfected cells [XREF_BIBR]."
21210219
reach
"It was discovered that inhibition of Ca 2+ -dependent protease calpain suppressed aggregation of polyglutamine expanded Atxn3 in transfected cells [XREF_BIBR]."
26023252
reach
"Based on observed fragment sizes and antibody binding, calpain mediated cleavage of ataxin-3 has been shown to occur most convincingly at amino acid 60, 221, and 260 [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
24293103
reach
"Calpain mediated ataxin-3 cleavage in the molecular pathogenesis of spinocerebellar ataxia type 3 (SCA3)."
23100324
reach
"Calpain inhibition is sufficient to suppress aggregation of polyglutamine expanded ataxin-3."
17488727
reach
"Calpain mediated cleavage of ataxin-3 has an important role in SCA3 pathogenesis [XREF_BIBR]."
19230774
reach
"It was discovered that inhibition of Ca 2+ -dependent protease calpain suppressed aggregation of polyglutamine expanded Atxn3 in transfected cells."
22353486
reach
"Calpain mediated ataxin-3 cleavage has also been proposed to be the determinant of neuronal specificity of pathology in SCA3."
24293103