IndraLab

Statements

CAPN activates ATXN3. 15 / 16
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"Calpain cleavage sites have been identified along the ataxin-3 protein, supporting the hypothesis of calpain mediated ataxin-3 proteolysis."
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"This phenotype could be abolished by calpain inhibition, indicating a key role of calpain in ATXN3 aggregation."
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"It was discovered that inhibition of Ca 2+ -dependent protease calpain suppressed aggregation of polyglutamine expanded Atxn3 in transfected cells."
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"It was discovered that inhibition of Ca 2+ -dependent protease calpain suppressed aggregation of polyglutamine expanded Atxn3 in transfected cells [XREF_BIBR]."
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"Calpain mediated cleavage of ataxin-3 has an important role in SCA3 pathogenesis [XREF_BIBR]."
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"However, ataxin-3 and α-fodrin cleavage could only be slightly induced by the calpain activator dibucaine ( Zhang et al., 2011 ) ( Fig. 5 D)."
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"The insoluble substances could completely disappear after treatment with a calpain inhibitor, elucidating the critical role of calpain-mediated ATXN3 cleavage in the formation of aggregates (Koch et al., 2011)."
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"Calpain mediated ataxin-3 cleavage in the molecular pathogenesis of spinocerebellar ataxia type 3 (SCA3)."
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"Calpain mediated ataxin-3 cleavage has also been proposed to be the determinant of neuronal specificity of pathology in SCA3."
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"In particular the role of calpain-mediated ataxin-3 cleavage in SCA3 pathogenesis is supported by convincing evidence ( Hübener et al., 2013; Koch et al., 2011 )."
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"Calpain inhibition reduces ataxin-3 cleavage alleviating neuropathology and motor impairments in mouse models of Machado-Joseph disease."
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"Based on observed fragment sizes and antibody binding, calpain mediated cleavage of ataxin-3 has been shown to occur most convincingly at amino acid 60, 221, and 260 [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
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"It has been hypothesized that the glutamate induced intracellular calcium increase activates calpain-mediated ataxin-3 cleavage and thus induces the formation of SDS-insoluble ataxin-3 aggregates ( Ko[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Calpain inhibition is sufficient to suppress aggregation of polyglutamine expanded ataxin-3."
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"It was discovered that inhibition of Ca 2+ -dependent protease calpain suppressed aggregation of polyglutamine expanded Atxn3 in transfected cells [XREF_BIBR]."
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