IndraLab

Statements

KCNH2 activates SQT1. 2 / 2
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"SQTS has been associated with the gain-of-function mutations in 3 distinct potassium channels, KCNH2, KCNQ1 and KCNJ2, which cause SQT1, SQT2 and SQT3, respectively [111-114]."
30027834
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"Since SQT1 is caused by an enhanced (a gain-of-function) hERG channel current, hERG channel blockers should be effective for prolonging QT interval or reducing the chance of arrhythmias in SQT1-patients."
34025432