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METTL3 activates USP13. 2 / 2

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"Furthermore, N 6 -methyladenosine methyltransferase-like 3 (METTL3) mediated stabilization of USP13 mRNA that required the m 6 A reader IGF2BP2."

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"Mechanically, USP13’s m A modification is catalyzed by METTL3, and IGF2BP2 promotes USP13 mRNA translation by identifying m A residues on USP13 transcripts, ultimately triggering autophagy [169]."

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IndraLab

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METTL3 activates USP13. 2 / 2

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