IndraLab

Statements

USP22 inhibits ITGB1. 3 / 3
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"In addition to integrin β1, USP22 deletion led to a slight cell surface reduction of several additional integrin family members including integrin α1-6 and integrin β2-3 and β5-7 but not β4, β8, and α7-8 expression determined by flow cytometry (Figure S2B)."
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"In addition, the loss of USP22 resulted in a significant reduction in FoxM1 binding to ITGB1 promoter (Figures 4A and 4B)."
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"In addition to integrin b1, USP22 deletion led to a modest but statistically significant reduction in several additional integrin family members including integrin a1–6 and integrin b2–3, b5–7, but not b4, b8 and a7–8 expression (Figure s2B), In contrast, integrin b6 expression is slightly increased in USP22-null breast cancer cells (Figure s2B)."
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