IndraLab
Statements
MTOR inhibitor decreases the amount of USP12. 1 / 1
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1
reach
"Treatment with inhibitors targeting MEK (U0126), ERK (ERK inhibitor), JNK (JNK inhibitor II), JAK-STAT3 (WP1066), c-Myc (c-Myc inhibitor), p38 MAPK (SB203580), and TGF-β-SMAD (SB431542 and SIS3) failed to produce a substantial change in USP12 expression (Supplementary Fig. 1e); however, blocking AKT-mTOR signalling using the selective AKT inhibitor API-2 or the mTOR inhibitor rapamycin significantly increased USP12 expression (Fig. 1i, j)."