IndraLab

Statements

ThiO activates KCNH2. 3 / 3
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reach
"These results indicate that THIO inhibited the hERG current without altering the kinetics of channel gating, suggesting that THIO mediated hERG channel damage is dependent on a decrease in protein levels."
32064022
reach
"These data provide evidence that THIO promotes hERG misfolding and degradation by inducing the dissociation of Hsp70 from hERG."
32064022
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"Our results demonstrated that THIO induced hERG channel deficiency but did not alter channel kinetics."
32064022