
IndraLab
Statements
reach
"T cell differentiation occurs in the thymus, and the relative expression of integrins accompanies the T cell maturation stage: immature cells are α4β1 /α5β1 , CD4/CD8 double-positive cells are α4β1 /α5β1 , and single-positive, mature T cells are α4β1 /α5β1 .36 T cells that express integrins α4β1 and α5β1 can bind VCAM-1 and fibronectin, respectively, and mediate leukocyte-EC-ECM interactions."