IndraLab

Statements


CD4 binds FN1. 6 / 6
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sparser
"We have resolved the adhesion strength and kinetics of individual CD4 binding to fibronectin."

sparser
"Specifically, the very late antigen (VLA)−4 (α4β1-integrin)-mediated interaction of resting human CD4 + T lymphocytes with fibronectin has been shown to promote CD3-mediated T cell proliferation ( xref )."

sparser
"An in vitro study has shown that CD4 + T cell binding to fibronectin is blocked by antibodies against the VLA-β1 chain (CD29) (Shimizu et al., 1990) , suggesting the necessity of surface CD29 molecu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

sparser
"Furthermore, taking advantage of ProteinChip technology, we analyzed the interaction of both proteins with CD4 and FN."

reach
"We have resolved the adhesion strength and kinetics of individual CD4 binding to fibronectin."

reach
"T cell differentiation occurs in the thymus, and the relative expression of integrins accompanies the T cell maturation stage: immature cells are α4β1 /α5β1 , CD4/CD8 double-positive cells are α4β1 /α5β1 , and single-positive, mature T cells are α4β1 /α5β1 .36 T cells that express integrins α4β1 and α5β1 can bind VCAM-1 and fibronectin, respectively, and mediate leukocyte-EC-ECM interactions."