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Estrogen increases the amount of KCNQ5. 2 / 2
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"Previously, we have shown that estrogen replacement in ovariectomized female guinea pigs increased the expression of KCNQ5 in the arcuate nucleus after both 24 hr and long-term treatment."

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"KCNQ5, RIMS2, and RAPGEF2 established connections between neurons and endocrine cells, such as estrogen treatment increasing KCNQ5 expression, which is crucial for regulating neural excitability [59,60,61]."