IndraLab

Statements


USP2 decreases the amount of CDKN1A. 2 / 2
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"As shown in Figure XREF_FIG, USP2 knockdown significantly increased p21 mRNA expression compared with MyLa2000 cells with control siRNA (p < 0.05)."

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"Given that USP2 knockdown reduced the levels of both SKP2 and SKP2 substrates, p21 and p27 (Fig. 6B), this growth inhibitory effect appears to be mediated by other substrates of USP2 in a manner largely independent of SKP2."