IndraLab

Statements

MT1 binds KCNK18. 2 / 2
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"Mutation in the gene encoding TRESK, a K2P channel, causes the formation of TRESK-MT1, the expected non-functional C-terminal truncated TRESK channel, and an additional unexpected protein, TRESK-MT2, which corresponds to a non-functional N-terminal truncated TRESK channel, through a mechanism called frameshift mutation-induced Alternative Translation Initiation (fsATI)."
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"The 20% remaining current was significantly further reduced by the expression of the specific TRESK dominant negative form TRESK-MT1 xref (Fig.  xref )."
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